Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi
نویسندگان
چکیده
In this work, we present the synthesis and anti-trypanosomal activity of 2-(4-(adamant-1-yl)phenyl)-N-hydroxyarylamides, 1a,b 2-(4-(adamant-1-yl)phenoxy)-N-hydroxyacetamide, 1c. The 4-(adamant-1-yl)phenyl- 4-(adamant-1-yl)phenoxy- moieties, which are endowed with promising drug-like properties, functionalized at side chain termini as hydroxamic acids. phenoxy acetohydroxamic derivative, 1c, shows most interesting profile in terms toxicity against trypanosomes merits further investigation.
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ژورنال
عنوان ژورنال: Molbank
سال: 2022
ISSN: ['1422-8599']
DOI: https://doi.org/10.3390/m1363